D-xylose test has been the subject of much investigative work of primary malaborption syndrone as
tropical or non-tropical sprue.
Recently it has also been tried in some of digestive disease.
In present study the author performes the 5 gm dose D-xylose test in 177 patietns receiving various
operations for digestive diseases.
The results obtained are as follows:
1) Differences between normail group (Mean:1.71±0.22gm in 5 hr urine by Hong´s 24) 5 gm oral
dose test with 67 normal Subjetcs) and groups receiving variuos operations are descpripted below.
a. For peptic ulcer, the mean value of D-xylose in 5hr urine of Group receiving Billroth Ⅰ type
operation (6 cases) and Group receiving vagotomy and drainage procedure (9 cases) are 1.68±0.17
gm, 1.73±0.06gm respectively and 0.03gm decrease (p＞0.3) o.02gm to normal group (p＞0.5)
which are not significant gastrectomy (20 cases) are 1/37±0.15gm, and 1.39±0/14gm respectively which
show significant decrease of 0.34gm (p＜0.005) and 0.32gm to normal group (p＜0.05).
b. For gastric cancer, the mean values od D-xylose group receiving subtotal gastrectomy (23
cases) and group receiving total gastrectomy (8 cases) disclose 1.43±0.22gm and 1.09±0.18gm
which are significant disease of 0.28gm(p＜0.05) and 0.62gm (p＜0.05) to normal group.
c. The mean value of D-xylose in 5 hr urine with 5gm oral dose of group (2 cases) with massive
resection of small intestine is 1.07±0.07gm which shows significant decrease of 0.64gm to normal
group (p＜0.001).
And there is no tedency of change in absorption power of D-xylose in group with partial removal
of small intestine, mechanically and fuctionally.
d. The mean value of D-xylose in 5hr urine with 5gm oral dose of patients(12 cases) in complete
external diversion of bile juice is 1.52±0.12gm and its difference with that of normal group is
significant decrease of 0.19gm (p＜0.005) which seems to be influenced by accompanying deranged liver
fuction rather than loss of bile juice itself.
e. Patients (9 cases) after receiving portasystemic shunt operation for portal hypertension show
significant decrease of 0.51gm to normal group with mean 1.20±0.17gm D-xylose in 5hr urine
with 5gm oral dose.
f. The meal value of D-xylose of group (17 cases) receiving appendectomy is 1.75±0.28gm and
there is no significance (p＜0.3) in 0.03gm increase to normal group.
2) In comparison of the various operations for peptic ulcer in the aspect of D-xylose absortion,
groups receiving BillrothⅠ type operations (6 cases) and vagotomy with drainage procedure (9 cases)
have superiority to groups receiving hemigastrectomy (17 cases) and subtotal gestrectomy (20 cases)
with 0.29gm increase in minimum and 0.36gm increase in maximum (p＜0.001).
3) Differnce in D-xylose absorption between group (23 cases) for peptic ulcer and group(23 cases)
for gastric cancer, receiving same subtotal gastrectomy is 0.04gm which is not significant (P＜0.1).
4) Group receiving subtotal gastrectomy (26 cases)for gastric cancer is superoir to group receiving
total gastrectomy (8 cases) for same causes with 0.34gm increase(p＜0.001).
5) there is no significance(p＞0.05) in difference of 0.04gm between group with colostomy (10
cases) and group with ileostomy (8 cases).
6) Group (12 cases) with total diversion of bile juice is inferior in 0.16gm decrease of D-xylose
absorption to group (15 cases) with partial diversion with significance. (p＜0.001).
7) In accordance with time interval, test scores obtained during postop. 6th to 10th day and
after postop. 20th dat show a tendency of increase of D-xylose absorption in group receiving subtotal
gastrectomy for peptic ulcer and group receiving portasystemic shunt operation which are 1.39±0.14
gm to 1.51±0.15gm(p＜0.05)and 1.20±0.17gm to 1.38±0.15gm(p＜0.05) respectively in the mean
value of D-xylose in 5hr urine.
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